abstract：BACKGROUND:De novo intraepidermal epithelioid melanocytic dysplasia (DNIEMD) is a newly characterized lesion that is associated with a personal and/or family history of malignant melanoma (MM) and/or dysplastic nevi (DN). However, the biological significance is still uncertain and the persons predisposed to this lesion...

journal_title：Journal of cutaneous pathology

authors： Jessup CJ,Cohen LM

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Hereditary hypotrichosis simplex (MIM 146520, HHS) is a rare form of nonsyndromic alopecia. The locus for autosomal dominant HHS was mapped to 18p11.32-p11.23 and 6p21.3, respectively, suggestive of genetic heterogeneity. AIM:To identify the disease-causing gene for a four-generation Chinese family with dom...

journal_title：Journal of cutaneous pathology

authors： Xu C,Zhang L,Chen N,Su B,Pan CM,Li JY,Zhang GW,Liu Z,Sheng Y,Song HD

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Direct immunofluorescence (DIF) testing is an important procedure in the diagnosis of autoimmune bullous dermatoses. We investigated the expression of C3d in formalin-fixed, paraffin-embedded tissue of autoimmune bullous dermatoses. METHODS:The immunohistochemical expression of C3d in bullous pemphigoid (BP...

journal_title：Journal of cutaneous pathology

authors： Pfaltz K,Mertz K,Rose C,Scheidegger P,Pfaltz M,Kempf W

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:To date, there has been no systematic investigation of the detailed histological features of prurigo nodularis (PN) in a large cohort of patients. METHODS:This retrospective study includes skin biopsies of 136 patients (63 males, 73 females; mean age: 58.38 years) with PN. RESULTS:Highly characteristic for...

journal_title：Journal of cutaneous pathology

authors： Weigelt N,Metze D,Ständer S

更新日期：2010-05-01 00:00:00

abstract：:The distinction of metastatic carcinomas to the skin from poorly differentiated primary cutaneous carcinomas and sometimes primary benign adnexal tumors can pose a significant diagnostic challenge. The purpose of this study was to evaluate the role of p63 and podoplanin (D2-40) immunoreactivity for separating primary ...

journal_title：Journal of cutaneous pathology

authors： Plaza JA,Ortega PF,Stockman DL,Suster S

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Alpha-methylacyl-CoA racemase (AMACR), also known as P504S, is a protein that plays an important role in mitochondrial and peroxisomal beta-oxidation of branched-chain fatty acid and bile acid intermediates. AMACR has been established as a valuable diagnostic marker for prostate cancer and has recently been ...

journal_title：Journal of cutaneous pathology

authors： Halsey MA,Calder KB,Mathew R,Schlauder S,Morgan MB

更新日期：2010-04-01 00:00:00

abstract：:Recent advances in the understanding of the metastatic phenomenon in cancer have led to the description of a metastatic niche. This concept describes a site prepared for the tumor cells in areas frequently associated with metastasis for the individual tumor studied. This niche is a "soil" that allows for the tumor cel...

journal_title：Journal of cutaneous pathology

authors： Mihm MC Jr,Nelson JS

更新日期：2010-04-01 00:00:00

abstract：:Malignant eccrine spiradenoma is an extremely rare skin tumor of sweat gland origin. In most cases, it arises in pre-existing benign eccrine spiradenoma. We report an additional case of malignant eccrine spiradenoma. The present case is of a 75-year-old man with malignant eccrine spiradenoma developed in the right sho...

journal_title：Journal of cutaneous pathology

authors： Ben Brahim E,Sfia M,Tangour M,Makhlouf R,Cribier B,Chatti S

更新日期：2010-04-01 00:00:00

abstract：:A case is presented of white plaques occurring predominantly on the vulvar mucosa of a 28-year-old female diagnosed as white sponge nevus (WSN). WSN is a rare, autosomal dominant disorder involving mucous membranes. It predominantly affects the oral mucosa; however, it has been reported to rarely involve extraoral muc...

journal_title：Journal of cutaneous pathology

authors： Cutlan JE,Saunders N,Olsen SH,Fullen DR

更新日期：2010-03-01 00:00:00

abstract：:We first report a case of granular cell histiocytosis occurring as a solitary polypoid lesion of the nipple in a 15-year-old girl. Histologically, the lesion was composed of a dermal population of medium- to large-sized, short spindle- to round- to epithelioid-shaped cells with eosinophilic cytoplasm containing numero...

journal_title：Journal of cutaneous pathology

authors： Caltabiano R,Magro G,Vecchio GM,Lanzafame S

更新日期：2010-02-01 00:00:00

abstract：:A prospective, controlled epidemiologic survey performed in El Bagre, Colombia revealed a new variant of endemic pemphigus disease, occurring in a gold mining region. The disease resembled Senear-Usher syndrome, and occurred in an endemic fashion. The aim of this study is to describe the most frequent histopathologic ...

journal_title：Journal of cutaneous pathology

authors： Howard MS,Yepes MM,Maldonado-Estrada JG,Villa-Robles E,Jaramillo A,Botero JH,Patiño PJ,Hashimoto T,Abreu-Velez AM

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine tumor arising predominantly on sun-exposed skin of older and usually immunosuppressed individuals. METHODS:Using data from NCI's SEER (Surveillance, Epidemiology, and End Results) Program from 1973 to 2006, we analyzed the demographics and ...

journal_title：Journal of cutaneous pathology

authors： Albores-Saavedra J,Batich K,Chable-Montero F,Sagy N,Schwartz AM,Henson DE

更新日期：2010-01-01 00:00:00

abstract：:Palisaded encapsulated neuroma (PEN; solitary circumscribed neuroma) is a benign, morphologically characteristic cutaneous or mucosal neuroma. Most are solitary lesions on the face, neck or oral mucosa. Histologically, the majority appears as dermal nodules of Schwann cell-rich fascicles, with or without distinctive e...

journal_title：Journal of cutaneous pathology

authors： Jokinen CH,Ragsdale BD,Argenyi ZB

更新日期：2010-01-01 00:00:00

abstract：:Cutaneous lesions of lupus erythematosus (LE) show a broad spectrum of clinicopathologic features. Histopathologically, besides typical patterns such as interface dermatitis, perivascular lymphocytic infiltrate and dermal mucin deposits, an involvement of the eccrine structures, especially the acrosyringium, may be ob...

journal_title：Journal of cutaneous pathology

authors： Fried I,Wiesner T,Cerroni L

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Molluscum contagiosum (MC) is a Molluscipox virus infection of keratinocytes with hyperplasia and intracytoplasmic inclusions - the molluscum bodies (MBs). Few papers address cytokeratins (K) profile in MC, mainly focusing terminal keratinization process. METHODS:Forty-one MC lesions were subjected to immun...

journal_title：Journal of cutaneous pathology

authors： Callegaro CF,Sotto MN

更新日期：2009-12-01 00:00:00

abstract：:An 11-year old Caucasian female with a remote history of urticaria pigmentosa presented with a neck mass. A biopsy demonstrated a large intradermal nodule composed of unusually large epithelioid mast cells, including a prominent subset with bi-lobed and multi-lobed nuclei. By immunohistochemistry, the cells expressed ...

journal_title：Journal of cutaneous pathology

authors： Tran DT,Jokinen CH,Argenyi ZB

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Cutaneous Rosai-Dorfman disease (CRDD) shares the histopathological features of abundant plasma cells and stromal fibrosis with IgG4-related sclerosing disease. The possible role of IgG4+ plasma cells in CRDD was investigated. METHODS:Twelve cases of CRDD were reviewed, and their lesions were immunostained ...

journal_title：Journal of cutaneous pathology

authors： Kuo TT,Chen TC,Lee LY,Lu PH

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Ulceration and osteoclast-like giant cells are two pathological features uncommonly seen in dermatofibromas. To our knowledge, the presence of these features has not been previously described within the same lesion. METHODS:We report the clinical, histopathological and immunohistochemical findings of a 38-y...

journal_title：Journal of cutaneous pathology

authors： González-Vilas D,García-Gavín J,Ginarte M,Rodríguez-Blanco I,Toribio J

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Scleroderma/morphea is characterized by expansion of the dermis with thickened collagen bundles and loss of CD34(+) dermal dendrocytes. Variable elastic fiber changes have been described, but to our knowledge, no systematic study of the elastic fiber pattern correlated with CD34 expression has been reported....

journal_title：Journal of cutaneous pathology

authors： Walters R,Pulitzer M,Kamino H

更新日期：2009-09-01 00:00:00

abstract：:Merkel cell carcinoma is occasionally associated with other types of cutaneous malignancies including squamous cell carcinoma, basal cell carcinoma and lentigo maligna. We report a case of Merkel cell carcinoma co-existent with sebaceous carcinoma in the right upper eyelid of a 61-year-old Japanese man. Histopathologi...

journal_title：Journal of cutaneous pathology

authors： Tanahashi J,Kashima K,Daa T,Yada N,Fujiwara S,Yokoyama S

更新日期：2009-09-01 00:00:00

abstract：:Dirofilaria repens (formerly Dirofilaria conjunctiva) is a natural parasite of the subcutaneous tissues of dogs, cats and wild carnivores in Europe, Africa and Asia. Microfilariae are transmitted to humans by various species of mosquito. An autochthonous case of subcutaneous dirofilariasis is reported in a Greek patie...

journal_title：Journal of cutaneous pathology

authors： Tzanetou K,Gasteratos S,Pantazopoulou A,Gogou C,Konidaris D,Fragia K

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:Silver dressings have been widely and successfully used to prevent cutaneous wounds, including burns, chronic ulcers, dermatitis and other cutaneous conditions, from infection. However, in a few cases, skin discolouration or argyria-like appearances have been reported. This study investigated the level of si...

journal_title：Journal of cutaneous pathology

authors： Wang XQ,Chang HE,Francis R,Olszowy H,Liu PY,Kempf M,Cuttle L,Kravchuk O,Phillips GE,Kimble RM

更新日期：2009-07-01 00:00:00

abstract：INTRODUCTION:The term spitzoid melanoma (SM) is reserved for a rare group of tumors with striking resemblance to Spitz nevus, often developing in children diagnosed in retrospect after the development of metastases. OBJECTIVES:To determine the biological significance of SM and to analyze the effectiveness of adjuvant ...

journal_title：Journal of cutaneous pathology

authors： Paradela S,Fonseca E,Pita S,Kantrow SM,Goncharuk VN,Diwan H,Prieto VG

更新日期：2009-07-01 00:00:00

abstract：:Sebaceous gland neoplasms such as adenoma, epithelioma, and carcinoma are uncommon cutaneous tumors. Although sporadic, their occurrence is clinically significant because of their association with Muir-Torre syndrome (MTS). MTS is a rare autosomal dominant genodermatosis characterized by the occurrence of sebaceous gl...

journal_title：Journal of cutaneous pathology

authors： Abbas O,Mahalingam M

更新日期：2009-06-01 00:00:00

abstract：:Cutaneous mixed tumors (MTs), also known as chondroid syringomas, usually arise as small nodules in the head and neck region. We describe an unusual case of a giant MT measuring 9 cm in its greatest diameter, occurring as a slowly growing pedunculated mass on the breast of a 74-year-old woman. Although MT may rarely o...

journal_title：Journal of cutaneous pathology

authors： Magro G,Floridia F,Geraci G,Marino B

更新日期：2009-06-01 00:00:00

abstract：:Chronic lymphocytic leukaemia (CLL) shows cutaneous involvement in 2% of cases. Merkel cell carcinoma (MCC) is a rare primary cutaneous epithelial neoplasm most commonly found in sun-exposed sites in elderly male Caucasians. A 66-year-old man presented with a 2-month history of a purple painless 2 cm tumor on the scal...

journal_title：Journal of cutaneous pathology

authors： Craig PJ,Calonje JE,Harries M,Stefanato CM

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Apocrine carcinomas are rare, the immunohistochemical characterizations that are incomplete. The purpose of this study was to determine the immunohistochemical characteristics of mucin core proteins and keratins in apocrine carcinoma, extramammary Paget's disease (EMPD) and apocrine nevus. METHODS:We report...

journal_title：Journal of cutaneous pathology

authors： Miyamoto T,Inoue S,Adachi K,Takada R

更新日期：2009-05-01 00:00:00

abstract：:We report a 20-year-old male patient with an atypical Spitz tumor, located in the dorsal aspect of his left hand, and a positive sentinel axillary lymph node. After lymphadenectomy, 1 of 23 non-sentinel lymph nodes excised was found to contain small multiple deposits of large spindle atypical melanocytes. Reviewing th...

journal_title：Journal of cutaneous pathology

authors： Urso C,Borgognoni L,Doria M,Tinacci G,Zini E

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Melanocytic nevi from the genitalia are uncommon. Nevi on the vulva are much better described than nevi on male genitalia. To our knowledge, a systematic study of preputial melanocytic nevi has not been reported. OBJECTIVE:To investigate the frequency of clinically unapparent melanocytic nevi on a series of...

journal_title：Journal of cutaneous pathology

authors： Val-Bernal JF,Val D,Garijo MF

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:p53 mutations are etiologically associated with the development of squamous cell carcinomas (SCCs) or with exposure to specific carcinogens. The study was conducted to examine the relationship of immunohistochemistry (IHC) scores between altered p53 protein expression in relation to patient's habits and hist...

journal_title：Journal of cutaneous pathology

authors： Bukhari MH,Niazi S,Chaudhry NA

更新日期：2009-03-01 00:00:00

abstract：:Galli-Galli disease (GGD) and Dowling-Degos disease (DDD) are inherited skin diseases with variable progressive course. They are of benign and harmless behaviour but aesthetically annoying. They are subsumed within the group of reticulate pigmented disorders of the skin to which, additionally, Kitamura's and Haber's d...

journal_title：Journal of cutaneous pathology

authors： Müller CS,Pföhler C,Tilgen W

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Becker nevus (BN) is a unilateral, hairy, pigmented cutaneous hamartoma that frequently appears in adolescence. Several features of BN suggest that increased androgen sensitivity plays a role in its pathogenesis. There have been only a few studies of histopathologic and immunohistochemical characteristics of...

journal_title：Journal of cutaneous pathology

authors： Kim YJ,Han JH,Kang HY,Lee ES,Kim YC

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Among the pigmented lesions with a central area of scar, we found a group of cases histologically characterized by striking architectural alteration of the melanocytic component, but with no cytological atypia and mitotically quiescent. The aim of the current study was to assess the biological nature of such...

journal_title：Journal of cutaneous pathology

authors： Fabrizi G,Pennacchia I,Pagliarello C,Massi G

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Cutaneous lymphocyte-associated antigen (CLA) is expressed in resident cutaneous T lymphocytes, high endothelial venules, peripheral monocytes, granulocytes and a small percentage of memory B cells. It has been postulated to be an important factor in homing of lymphocytes to the skin because of its function ...

journal_title：Journal of cutaneous pathology

authors： Magro CM,Dyrsen ME

更新日期：2008-11-01 00:00:00

abstract：:A 46-year-old man had a cystic mass on the right side of his scalp. Histological examination revealed a cystic dermal nodule composed of relatively circumscribed lobules of proliferating squamous epithelium, with atypical mitoses and dyskeratotic cells of invasive structure, which was diagnosed as proliferating tricho...

journal_title：Journal of cutaneous pathology

authors： Masui Y,Komine M,Kadono T,Ishiura N,Maekawa T,Ihn H,Kikuchi K,Tamaki K

更新日期：2008-10-01 00:00:00

abstract：:Lichen aureus is a rare disease of unknown origin that is classified under the group of pigmented purpuric dermatoses. Its most important differential diagnosis is both clinically and histologically mycosis fungoides, into which the disease can proceed in very rare cases. We describe an unusual multilocular lichen aur...

journal_title：Journal of cutaneous pathology

authors： Yazdi AS,Mayser P,Sander CA

更新日期：2008-10-01 00:00:00

abstract：:The dermatological disorders associated with monoclonal gammopathies are clinically heterogeneous and may be divided into four groups with distinctive pathogenetic mechanisms (a) specific (infiltrative) disorders including primary and secondary cutaneous plasmacytoma and cutaneous lymphoplasmacytic infiltration of Wal...

journal_title：Journal of cutaneous pathology

authors： Rongioletti F,Patterson JW,Rebora A

更新日期：2008-08-01 00:00:00

abstract：:We report a 2-year-old girl with developmental delay who, from the age of 1 year, developed perniotic lesions of the hands and feet initially diagnosed as chilblain lupus. Histological examination showed features of epidermal necrosis with intraepidermal bulla formation, interface dermatitis, lymphocytic vasculitis wi...

journal_title：Journal of cutaneous pathology

authors： Kolivras A,Aeby A,Crow YJ,Rice GI,Sass U,André J

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:The distinction between ocular sebaceous carcinoma, poorly differentiated ocular squamous cell carcinoma and ocular basal cell carcinoma can be challenging. An appropriate immunohistochemical panel may help to differentiate these lesions. METHODS:To determine the distribution and use of several immunostains...

journal_title：Journal of cutaneous pathology

authors： Sramek B,Lisle A,Loy T

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Langerhans' cells (CD1a positive, bone marrow-derived cells), are the antigen presenting cells of the skin. Our knowledge about the status of these cells in eczematous dermatitis is incomplete. AIM:This study tests the hypothesis that 'the development of eczematous dermatitis is associated with alterations ...

journal_title：Journal of cutaneous pathology

authors： Hussein MR

更新日期：2008-06-01 00:00:00